Cysteine endopeptidases

Human Bleomycin Hydrolase: Molecular Cloning, Sequencing, Functional Expression, and Enzymatic Characterization

Biochemistry / Kinetics / Gene expression / Saccharomyces cerevisiae / Cell line / Humans / Animals / Polymerase Chain Reaction / Molecular cloning / Substrate Specificity / Cysteine endopeptidases / Cysteine / Transfection / Molecular weight / Bleomycin / Amino Acid Sequence / Base Sequence / Recombinant Proteins / Asparagine / Histidine / Biochemistry and cell biology / Molecular Sequence Data / Humans / Animals / Polymerase Chain Reaction / Molecular cloning / Substrate Specificity / Cysteine endopeptidases / Cysteine / Transfection / Molecular weight / Bleomycin / Amino Acid Sequence / Base Sequence / Recombinant Proteins / Asparagine / Histidine / Biochemistry and cell biology / Molecular Sequence Data

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A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release

Microbiology / Virulence / Experimental parasitology / Mutation / Animals / Experimental / Microarray Analysis / Phagocytosis / Entamoeba histolytica / Cysteine endopeptidases / Virulence factor / Veterinary Sciences / Microspheres / Calcium Binding Proteins / Virulence Factors / Calcium Binding Protein / Enzyme Linked Immunosorbent Assay / Experimental / Microarray Analysis / Phagocytosis / Entamoeba histolytica / Cysteine endopeptidases / Virulence factor / Veterinary Sciences / Microspheres / Calcium Binding Proteins / Virulence Factors / Calcium Binding Protein / Enzyme Linked Immunosorbent Assay

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Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins

Mass Spectrometry / Medical Microbiology / Malaria / Calcium / Humans / Endothelial Cells / Animals / Plasmodium falciparum / Muscle contraction / Cysteine endopeptidases / Ileum / Kinins / Endothelial Cells / Animals / Plasmodium falciparum / Muscle contraction / Cysteine endopeptidases / Ileum / Kinins

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S 1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids

Thermodynamics / Kinetics / Humans / Animals / Drug Design / Peptides / Substrate Specificity / Cysteine endopeptidases / Amino Acid Profile / Protozoan Proteins / Recombinant Proteins / Hydrolysis / Biochemistry and cell biology / Cysteine Proteinase Inhibitors / Peptides / Substrate Specificity / Cysteine endopeptidases / Amino Acid Profile / Protozoan Proteins / Recombinant Proteins / Hydrolysis / Biochemistry and cell biology / Cysteine Proteinase Inhibitors

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Lysosomes as photochemical targets

Cancer / Porphyrins / Light / Cysteine endopeptidases / Lysosomes / Hydrogen-Ion Concentration / Cell Survival / Hydrogen-Ion Concentration / Cell Survival

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Mannose-specific interaction of Lactobacillus plantarum with porcine jejunal epithelium

Microbiology / Immunology / Probiotics / Medical Microbiology / Gene expression / Intestinal Mucosa / Animals / Male / Jejunum / Behavioral Animal Models / Intestinal absorption / Swine / Lactobacillus Plantarum / Cysteine endopeptidases / Cell Wall / Mannose / Cell Surface Markers / Small Intestine / Intestinal Mucosa / Animals / Male / Jejunum / Behavioral Animal Models / Intestinal absorption / Swine / Lactobacillus Plantarum / Cysteine endopeptidases / Cell Wall / Mannose / Cell Surface Markers / Small Intestine

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Mannose-specific interaction of Lactobacillus plantarum with porcine jejunal epithelium

Microbiology / Immunology / Probiotics / Medical Microbiology / Gene expression / Intestinal Mucosa / Animals / Male / Jejunum / Behavioral Animal Models / Intestinal absorption / Swine / Lactobacillus Plantarum / Cysteine endopeptidases / Cell Wall / Mannose / Cell Surface Markers / Small Intestine / Intestinal Mucosa / Animals / Male / Jejunum / Behavioral Animal Models / Intestinal absorption / Swine / Lactobacillus Plantarum / Cysteine endopeptidases / Cell Wall / Mannose / Cell Surface Markers / Small Intestine

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An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites

Organic Chemistry / Malaria / Humans / Drug Resistance / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Chloroquine / Structure activity Relationship / Erythrocytes / Hemoglobins / Cysteine Proteinase Inhibitors / Antimalarials / Cysteine endopeptidases / Chloroquine / Structure activity Relationship / Erythrocytes / Hemoglobins / Cysteine Proteinase Inhibitors

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Nuclear Legumain Activity in Colorectal Cancer

Engineering / Physics / Chemistry / Biology / Immunohistochemistry / Confocal Microscopy / Medicine / Multidisciplinary / RNA interference / Humans / Mutation / Mice / Female / Animals / PLoS one / Cell nucleus / Peer reviewed / Cysteine endopeptidases / Amino Acid Sequence / Lysosomes / Immunoblotting / Confocal Microscopy / Medicine / Multidisciplinary / RNA interference / Humans / Mutation / Mice / Female / Animals / PLoS one / Cell nucleus / Peer reviewed / Cysteine endopeptidases / Amino Acid Sequence / Lysosomes / Immunoblotting

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Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

Cell Biology / Apoptosis / Disease susceptibility / Biological Sciences / Humans / Intestinal Mucosa / Mice / Animals / Bacteria / The / Cytoprotection / Phenotype / Colitis / Tumor necrosis factor-alpha / Experimental Medicine / Cysteine endopeptidases / Tumor Necrosis Factor–α (TNF) / Enterocytes / Intestinal Mucosa / Mice / Animals / Bacteria / The / Cytoprotection / Phenotype / Colitis / Tumor necrosis factor-alpha / Experimental Medicine / Cysteine endopeptidases / Tumor Necrosis Factor–α (TNF) / Enterocytes

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A comparison of Pfam and MEROPS: Two database, one comprehensive, and one specialised

Peer Review / Quality Control / Biological Sciences / Mycobacterium tuberculosis / Mathematical Sciences / Animals / hidden Markov model / BMC Bioinformatics / Enzyme / Multienzyme complexes / Cysteine endopeptidases / Sensitivity and Specificity / Animals / hidden Markov model / BMC Bioinformatics / Enzyme / Multienzyme complexes / Cysteine endopeptidases / Sensitivity and Specificity

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Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon

Complementary and Alternative Medicine / Plant Biology / Cameroon / Ethnopharmacology / Medicinal Plants / Phytotherapy / Animals / Plant extracts / Angiosperms / Euphorbiaceae / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Biological activity / Erythrocytes / Annonaceae / Moraceae / Medicinal Plant / Phytotherapy / Animals / Plant extracts / Angiosperms / Euphorbiaceae / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Biological activity / Erythrocytes / Annonaceae / Moraceae / Medicinal Plant

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Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins

Mass Spectrometry / Medical Microbiology / Malaria / Calcium / Humans / Endothelial Cells / Animals / Plasmodium falciparum / Muscle contraction / Cysteine endopeptidases / Ileum / Kinins / Endothelial Cells / Animals / Plasmodium falciparum / Muscle contraction / Cysteine endopeptidases / Ileum / Kinins

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Cystatin C Deficiency Increases Elastic Lamina Degradation and Aortic Dilatation in Apolipoprotein E-Null Mice

Extracellular Matrix / Basement Membrane / Collagen / Mice / Animals / Male / Clinical Sciences / cystatin C / Circulation / Cysteine endopeptidases / Cell Proliferation / Abdominal Aortic Aneurysm / Male / Clinical Sciences / cystatin C / Circulation / Cysteine endopeptidases / Cell Proliferation / Abdominal Aortic Aneurysm

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Cystatin C Deficiency Increases Elastic Lamina Degradation and Aortic Dilatation in Apolipoprotein E-Null Mice

Extracellular Matrix / Basement Membrane / Collagen / Mice / Animals / Male / Clinical Sciences / cystatin C / Circulation / Cysteine endopeptidases / Cell Proliferation / Abdominal Aortic Aneurysm / Male / Clinical Sciences / cystatin C / Circulation / Cysteine endopeptidases / Cell Proliferation / Abdominal Aortic Aneurysm

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FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma

Apoptosis / Signal Transduction / Caspases / Cell line / Humans / Chronic Lymphocytic Leukemia / Mice / Animals / Blood / Organ Transplantation / Clinical Sciences / Mouse Model / Cysteine endopeptidases / B Lymphocytes / Okadaic acid / Sphingosine / Down-Regulation / Chronic Lymphocytic Leukemia / Mice / Animals / Blood / Organ Transplantation / Clinical Sciences / Mouse Model / Cysteine endopeptidases / B Lymphocytes / Okadaic acid / Sphingosine / Down-Regulation

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